The struggle for independence in the Quito Audiencia was part of a movement throughout Spanish America led by criollos [persons of pure Spanish descent born in the New World]. The criollos resentment of the privileges enjoyed by the peninsulares was the fuel of revolution against colonial rule. The spark was Napoleon's invasion of Spain, after which he deposed King Ferdinand VII and, in July 1808, placed his brother Joseph Bonaparte on the Spanish throne.

Shortly afterward, Spanish citizens, unhappy at the usurpation of the throne by the French, began organizing local juntas loyal to Ferdinand. A group of Quito's leading citizens followed suit, and on August 10, 1809, they seized power from the local representatives of Joseph Bonaparte in the name of Ferdinand. Thus, this early revolt against colonial rule [one of the first in Spanish America] was, paradoxically, an expression of loyalty to the Spanish king.

It quickly became apparent that Quito's criollo rebels lacked the anticipated popular support for their cause. As loyalist troops approached Quito, therefore, they peacefully turned power back to the crown authorities. Despite assurances against reprisals, the returning Spanish authorities [Bonaparte's men] proved to be merciless with the rebels and, in the process of ferreting out participants in the Quito revolt, jailed and abused many innocent citizens. They actions, in turn, bred popular resentment among Quitenos, who, after several days of street fighting in August 1810, won an agreement to be governed by a junta to be dominated by criollos, although with the president of the Audiencia of Quito acting as its figurehead leader.

In spite of widespread opposition within the rest of the Quito Audiencia , the junta called for a congress in December 1811 in which it declared the entire area of the audiencia to be independent. Two months later, the junta approved a constitution for the state of Quito that provided for democratic governing institutions but also granted recognition to the authority of Ferdinand should he return to the Spanish throne. Shortly thereafter, the junta elected to launch a military offensive against the Spanish, but the poorly trained and badly equipped troops were no match for those of the viceroy of Peru, which finally crushed the Quiteno rebellion in December 1812.

The second chapter in Ecuador's struggle for emancipation from Spanish colonial rule began in Guayaquil, where independence was proclaimed in October 1820 by a local patriotic junta under the leadership of the poet Jose Joaquin Olmedo. By this time, the forces of independence had grown continental in scope and were organized into two principal armies, one under the Venezuelan Simon Bolivar Palacios in the north and the other under the Argentine Jose de San Martin in the south. Unlike the hapless Quito junta, the Guayaquil patriots were able to appeal to foreign allies, Argentina and Venezuela, each of whom soon responded by sending sizable contingents to Ecuador. Antonio Jose de Sucre Alcala, the brilliant young lieutenant of Bolkvar who arrived in Guayaquil in May 1821, was to become the key figure in the ensuing military struggle against the royalist forces.

After a number of initial successes, Sucre's army was defeated at Ambato in the central Sierra and he appealed for assistance from San Martin, whose army was by now in Peru. With the arrival from the south of 1,400 fresh soldiers under the command of Andres de Santa Cruz Calahumana, the fortunes of the patriotic army were again reversed. A string of victories culminated in the decisive Battle of Pichincha, on the slopes of the volcano of that name on the western outskirts of Quito, on May 24, 1822. A few hours after the victory by the patriots, the last president of the Audiencia of Quito signed a formal capitulation of his forces before Marshal Sucre. Ecuador was at last free of Spanish rule.

Two months later Bolivar, the liberator of northern South America, entered Quito to a hero's welcome. Later that July, he met San Martin in Guayaquil and convinced the Argentine general, who wanted the port to return to Peruvian jurisdiction, and the local criollo elite in both major cities of the advantage of having the former Quito Audiencia join with the liberated lands to the north. As a result, Ecuador became the District of the South within the Confederation of Gran Colombia, which also included present-day Venezuela and Colombia and had Bogota as its capital. This status was maintained for eight tumultuous years.

They were years in which warfare dominated the affairs of Ecuador. First, the country found itself on the front lines of Bolivar's war to liberate Peru from Spanish rule between 1822 and 1825; afterward, in 1828 and 1829, Ecuador was in the middle of an armed struggle between Peru and Gran Colombia over the location of their common border. After a campaign that included the near destruction of Guayaquil, the forces of Gran Colombia, under the leadership of Sucre and Venezuelan General Juan Jose Flores, proved victorious. The Treaty of 1829 fixed the border on the line that had divided the Quito audiencia and the Viceroyalty of Peru before independence.

The population of Ecuador was divided during these years